How do these two compare in actual usage, which battery last longer?

Trust me I'll do an in-depth comparison as soon as I have a 2410-22 in hand, which should be very soon. The batteries both have 3 lithium ion cells so they should be very similar in run time but I will test it in person anyway. Check back in the next week or two.

Don't overlook the Hitachi DS10DFL. While the paper specs may be slightly less(195 in/lb torque; 0-300/1,300 RPM), the drill costs $50 less is an excellent tool.

How about the makita DF330dw - also new, and weighs less than both these - Im trying decide between the milwaukee and the makita. They are closer to each other than the Bosch i think.

Ive been using this m12 drill for a couple weeks now at work and all over the house, this is an EXCELLENT drill and easily keeps up with the 18v drills in all but the toughest of jobs, the batteries last me about 3 hours of continous use, and recharge in 30 minutes or less, you will not be dissappointed if you purchase this tool...

I will be driving a screw, and before you know it the chuck will loosen on the apex(magnetic bit holder). Seems like the chuck strength doesn't match the drills.
I like the size and weight of the M12 drill,
I wonder if there will be a problem with the chucks?

I'm returning my Milwaukee 2410-22 because of problems: #1 - the chuck loosening up on its own. #2 - speed switch gets stuck in between high and low. Other than those problems, this is a nice tool. Balance was great, battery life decent: lasted me 5-6 hrs constant use.
If they work out the problems, a great tool. Till then I'm going for the Makita DF330DW.

I'm also deciding between Milwaukee M12 and Makita DF330DW - and the last comment may have just tilt the scale enough for me to favor Makita. Pop Mechanics review (Dec 2009) liked both of these very much with Milwaukee taking top honors (mostly due to better torque and speed due to 12vdc versus Makitas 10.8vdc)

Correct me if I'm wrong, but I believe that there is no real difference between the 12v and the 10.8v versions of these tool, regardless of the company that produces them. As I understand it, they are all 12 volt at the beginning and then average out at 10.8 volts. So the companies who list their tool at 10.8 are going off the average voltage and those who list it at 12v are going off the initial voltage. Calling them 12v is a marketing ploy. Bosch's was also labeled 10.8v, but they changed it to 12v in order to avoid the confusion and better compete with other companies who label theirs as 12v.

You are right the Makita 10.8V batteries are pretty much the same as bosch and Milwaukee 12V. I think we have all come to realize this class of tools can be very useful and I am happy to see more and more pro tools on these platforms.

I just bought this tool, and after two days of use, am very disappointed. First the good: Lots of torque, speed, and chuck runs very true, quick charge, long life. Now the bad: 1) Chuck does not close down on very small drillbits, as chuck teeth are rounded off (my old Makita doesn't have this issue). 2) The large chuck creates a shadow from LED light, making the drill, hole, or screwhead completely dark - why have a light, if the chuck creates a dark shadow? 3) As already mentioned, the chuck can't hold tight after repeated use, no matter how tight you tighten it. 4) The speed control whines like crazy at low speeds (thought first one was bad, took it back, same with second unit). I really wanted a new drill, as my ancient Makita is wearing out, but this one just didn't cut it. In fact, when comparing side by side, the oldie but goodie wasn't that much larger and had better balance and better hand position when torquing tight screws.

I finally bought this drill and have been using it for about a month now. I am very happy with it.

For me, the decision was between the Milwaukee and the Bosch. I wanted to go with Bosch, because I have two other Bosch cordless tools. But the deciding factor was the fact that the Milwaukee has double the RPM of the Bosch. As for the Makita, in addition to the fact that the black and white color scheme is hideous, like the Bosch, its maximum RPM of 1300 is about half of the Milwaukee's, which is 2500 RPM. That is a big difference. So that outweighed the inconvenience of having two different types of batteries and battery chargers.

With regard to the chuck issue, any drill with a key-less chuck is going to have a tendency to loosen up if you don't crank it down tight enough. And getting it tight enough that it will never loosen up is hard to do by hand. I don't think the Milwaukee compact drill is any different than any other drill with a key-less chuck. I haven't used really small bits though, so maybe it is more problematic with those than other drills; I don't know. One way to help avoid this problem, though, is to use hex bits. Milwaukee makes a set of hex drill bits that comes with one of those quick change things. That way, you just ratchet the quick change piece down like crazy, and then you don't have to mess with it any more. And you can use it for either drill bits or driver bits.

I don't find the shadow to be an issue. First, the problem varies depending on the type of bit you are using and how far it extends from the chuck. Also, when it is a problem, it is only when you are looking from above the drill. If you look from below the drill, there is no shadow issue. So I don't find this to be that big of a deal.

Finally, the whining at low RPMs that Master Blaster mentioned, also not a big deal. Maybe this is an effect of the greater torque. But frankly I don't think it is all that loud.